Introduction: Drug associations are very frequent among patients, and these associations should be optimized and personalized in aim to reduce adverse drug reactions and to improve the quality of the treatment. Material and method: This is a retrospective study, during which we have analyzed 2000 case report forms and ambulatory care forms, evaluating finally 600 cases. Results: All of the included patients were suffering from a cardiovascular disease, most frequently arterial hypertension (57.1%). The most frequent prognostically important associated diseases were diabetes mellitus (26.73%) and metabolic syndrome (13.2%). Interestingly 71% from our patients were receiving five or more medicines simultaneously. The most frequent associations were cardiovascular drugs and a diuretic, respectively a respiratory tract drug. Discussion: Multiple drug associations are very frequent. The treatment could be improved and the adverse drug reactions could be reduced if these associations were analyzed from the point of view of clinical pharmacology.
Keywords: drug association, pharmacotherapy, adverse reaction