The objective of the research was to obtain easier-to-prepare and microbiologically more stable multi-dose eye drops with chloramphenicol than the official one in the IXth edition of the Romanian Pharmacopoeia. Two metods were applied: lyophilizing and mixing in two molar reports (1:1 and 2:1 ß-cyclodextrin-chloramphenicol) inclusion complexes. The training was verified by infrared spectrophotometric analysis and solubility in water. Multi-dose eye solutions were obtained with these complexes. The preservation of these solutions was achieved with phenyl mercuric borate solution 0,2%. The microbiological study of two culture media showed a better stability of the solutions prepared with the inclusion complexes.
Keywords: chloramphenicol, eye drops, inclusion complexes