Preparation and characterization of hydrophil matrix retard tramadol tablets

Written by Rédai Emőke, Sipos Emese, Ciurba Adriana, Todoran Nicoleta, Szabó Zsófia

Tramadol, used to treat moderate to moderately severe pain, presents less of the characteristic side effects of morphine derivates. Its half life time makes tramadol suitable for retardation. The aim of this study was to obtain hydrophil polymer-based matrixes for sustained release. We compared the dissolution profile of our tablets with the dissolution profile of generic tramadol tablets. Two types of hydrophilic matrix excipients were used, Carbopol 940 and hydroxypropylmethylcellulose 15000. Carbopol was used in two different concentrations 5% respective 7,5%, hydroxypropylmethylcellulose in 20%. Our result indicates that among the three studied formulations the 20% hydroxypropylmethylcellulose contanting tablets present a similar dissolution profile with the industrial tablets, presenting prolonged liberation of the active substance.


Keywords: tramadol, retard tablet, hydrophilic matrix

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