Microequilibria at inclusion complexes. III. A particular case of the Linear Free-Energy Relations

Written by Kun Csilla, Tőkés Béla, Donáth-Nagy Gabriella, Vancea Szende

The aim of this work is to expand the rules applicable to the partition processes on the formation of inclusion complexes of cyclodextrins, considering these interactions as partition microequilibria of the host molecule between the nonpolar cyclodextrin cavity and the polar external environment. We obtained relations between the stability constants of inclusion complexes of dicarboxylic acids and the calculated n-octanol/water partition coefficients. These results confirmed and documented from several directions our initial assumption concerning microequilibria.


Keywords: inclusion complexes, cyclodextrins, partition coefficient, dicarboxylic acid

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