Modification of the cutaneous microvascular perfusion in chronic venous disorder evidentiated with laser Doppler flowmetry

Written by Balogh Zsolt Elek, Puskás Attila, Farkas Katalin, Egresits József, Imre Mihály, Brassai Zoltán

The pathophysiological basic of the chronic venous disorder (CVD) is the venous reflux, the consequent orthostatical venous hypertension, and the alterations of the cutaneous microcirculation. The aim of this study was to examine the microcirculation in CVD patients. 40 patients, regardless to the etiology, were enrolled in two groups on the basis of CEAP classification. The first group was that of the early stage CVD- (C1-C3) (N: 20) patients, and the second one was that of the advanced stages CVI patients (C4-C6) (N: 20). The evaluation of global reflux was done by photoplethysmography. There was also performed a laser Doppler flowmetry, in each patient 2-3 cm above the medial ankle. After the basal flow registration, there were done different provocative tests (postural vasoconstrictor response, local electrode heating). The results were statistically compared with the results of a healthy control group (N: 20). Our results show, that the cutaneous capillary network is probably protected from the bidirectional (venous and arterial) pressure load, by the increasing of the postural vasoconstrictor response. The progressive decreasing of the vasodilatator mechanisms could show the alteration of the fast, C-fibre dependent, and the late, endothelial-dependent (nitric-oxide) vasodilatation.

Print   Email