Aims. We studied the risk factors of the advanced stages of this serious disease affecting a great part of the population; the clinical symptoms, the way it affects one’s capacity to work; the C.E.A.P. system disease stages (C – Clinically, E – etiologically, A – anatomically, the affected venous segments, P – Pathophisiologically, hemodynamic properties), the correlations between these parameters, as an overview of the therapeutic challenges and possibilities. Material and methods. In our study we examined a number of 100 patients with advancedstage chronic venous insufficiency (C4, C5, C6), who visited the Ambulatory Department of the 2nd Internal Medicine Clinic with angiologic profile, from Targu Mures. Following a detailed questionnaire, we proceeded to targeted clinical examinations, as the CW Doppler and Echo Duplex sonographic scans. Results. We found answers to those Anatomical, (affected venous segment, trunk diameter of the safenous vein) and Hemodynamic parameters (the most proximal point of the reflux, length of the involved vein segment) that are unequivocal characteristics of these stages. They also, have a predictive value concerning the to recommendation of surgical treatment, or the prescription of a high-grade compressive treatment. Through our study, we wish to underline the great importance of the fair use of proper diagnostic and therapeutic measures in the management of the advanced stages of this widespread disease.