Nowadays the emergence of Hepatitis C Virus infections is recognized and well established all over the world. Assessment of the real dimensions of acute and chronic pathology due to Hepatitis C Virus is of permanent concern. The results of epidemiological surveillance, in the absence of specific prophylaxis and efficient etiological therapy are means for the development non specific preventive measures development. Based on a thorough study of one epidemic episode of hepatitis C virus nosocomial infection, in the context of population studies of acute morbidity incidence, anamnestic infection prevalence and C viral hepatitis pathology weight, useful conclusions for epidemiology practice in avoiding/decreasing nosocomial transmitted C viral hepatitis can be drawn.